Web4. Future direction: a therapy targeting specifically DDX3Y? The finding that the DDX3Y protein, undetectable in normal human B cells, is aberrantly expressed in cancerous B … WebThe LV-DDX3X-RNAi lentiviral vector (GeneChem Co., Ltd., Shanghai, China) was transfected into SW480 and HCT116 cells to construct the DDX3 knockdown cell line. ... RK33 is a small molecule inhibitor of DDX3 that interferes with the helicase activity of DDX3 by docking with the ATP-binding gap of DDX3 .
DDX3 inhibitor RK-33. a. Structure of 5:7:5 tricyclic heterocycle ...
WebOct 26, 2024 · DDX3 (DEAD-box helicase 3 X-linked; gene symbol DDX3X), the ortholog of Belle in mammalian cells, has been implicated in multiple cancers including CaP ... This … WebJan 9, 2024 · Since (1) DDX3X is an essential host co-factor for the replication of multiple viruses, (2) inhibitors of DDX3X can act as broad-spectrum antivirals [17,18] and (3) REN … raanimukarji hits songs
Full article: DDX3: a relevant therapeutic target for lymphoma?
WebRK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells. All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use. RK33, CAS 1070773-09-9. WebThese findings establish for the first time that RK-33 is a broad-spectrum antiviral agent that blocks DDX3X’s catalytic activities in vitro and limits viral replication in cells. Viral disease … WebJan 1, 2024 · With the use of a small molecule inhibitor of DDX3, RK-33, we could inhibit growth and promote cell death in two medulloblastoma cell lines, DAOY and UW228, with … raanjai