Phenytoin receptor
Webof phenytoin analogs A search of the literature yielded data for over 800 analogs of phenytoin, about one quarter of which had been evaluated comparably using maximal electroshock techniques. Structure- activity studies have led to the view (6) that the phenytoin receptor interacts with the drug primarily through the formation WebPhenytoin induction of the cyp2c37 gene is mediated by the constitutive androstane receptor. The CYP2C subfamily of cytochrome P450 monooxygenases is responsible for …
Phenytoin receptor
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Web27. mar 2024 · Phenytoin appeared to be a drug of enriched pharmacology, or a ‘dirty’ drug, as it has affinity for a number of targets in the family of voltage gated sodium channels, the L-type calcium channel and some extra receptors such as the GABA-A receptor. Therefore, phenytoin is more than a broad acting ion channel blocker only, and this might be ... WebPhenytoin is highly protein-bound (90%), mostly to albumin. Ten percent of the phenytoin circulates in the free, unbound form. Free phenytoin is the active form of the drug, available to cross biologic membranes and bind to receptors. Increased free phenytoin produces an enhanced pharmacologic effect.
Web1. apr 2005 · In guinea pig brain membranes, coincubation with phenytoin was used to reportedly increase the binding affinity of putative sigma-1 receptor agonists while slightly decreasing the affinity of... WebPočet riadkov: 22 · Phenytoin is considered an ASM for a variety of seizure types with noted emphasis on acute treatment of seizures. PHT was originally synthesized by Heinrich …
Web30. dec 2015 · Rationale: Phenytoin (Dilantin® DPH) is used to treat epilepsy but causes estrogen agonist–antagonist-like side effects. We investigated the interaction of … WebFosphenytoin is a phosphate ester prodrug developed as an alternative to intravenous phenytoin for acute treatment of seizures. Advantages include more convenient and rapid …
Web30. dec 2015 · Rationale: Phenytoin (Dilantin® DPH) is used to treat epilepsy but causes estrogen agonist–antagonist-like side effects. We investigated the interaction of phenytoin with estrogen receptors (ERs) α and β by computational molecular docking, ER competition binding, transcriptional assays, and biological actions, comparing outcomes with estradiol …
Web1. aug 2024 · Phenytoin is an anti-seizure drug that has been under clinical evaluation for around eight decades. It is primarily used for the treatment of tonic-clonic and partial seizures (Abou-Khalil, 2016). Phenytoin has a highly selective inhibitory effect on the motor area of the cerebral cortex. hawking electrotechnology ltdWebNational Center for Biotechnology Information boston guardian newspaper boston maWebThe nuclear receptor PXR appears to be responsible for induction of MDR1, causing activation of P-gp in a dose- and site-dependent manner (83). Coinducers of P-gp and CYP3A include phenobarbital, phenytoin, dexamethasone, rifampin, and St. John's wort (84–86). Following reports of substantial decreases in digoxin concentrations in patients ... hawking elementary schoolWeb27. jan 2015 · Effect of phenytoin on breast tumour growth. (A) Tumour section stained with (i) anti-Na v 1.5 or (ii) anti-Na v 1.7 (red) and DAPI (blue). T, tumour, F, fibroadipose tissue. Scale bar, 100 μm. (B) Phenytoin dosing protocol. BLI, bioluminescent imaging. (C) Weight of mice during the assay.(D) Bioluminescent images of control and phenytoin-treated … boston gsw scoreWeb1. apr 2024 · SIGNIFICANCE STATEMENT We show that phenytoin, a Na channel blocker used clinically for treatment of epilepsy, is a diastolic inhibitor of cardiac calcium release … hawking elizabethan eraWebPhenytoin is a major anticonvulsant drug that is very effective in controlling a wide variety of seizure disorders while impairing neurological function little, if at all. Early work … hawkinge medical centreWeb24. aug 2024 · CYP2C9 is involved in the metabolism of approximately 15–20% of clinically used drugs, such as anticoagulants ( S -acenocoumarol, S -warfarin), antiepileptics (phenytoin, valproate), non-steroid... hawkinge music festival