Gpr146 cell research
Webprobable G-protein coupled receptor 146 Background GPR146 is an Orphan-U GPCR with an unknown ligand, but is likely to be a chemokine receptor. Limitations This product is … WebOct 23, 2024 · Hypercholesterolemia risk-associated GPR146 is an orphan G-protein coupled receptor that regulates blood cholesterol levels in humans and mice. GPR146: an emerging therapeutic target for hypercholesterolemia and atherosclerosis. these findings outline a regulatory role for the GPR146/ERK axis in systemic cholesterol metabolism.
Gpr146 cell research
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WebMar 20, 2024 · However, eQTL analysis in humans showed that the strongest association with GPR146 expression is in whole blood cells. Thus, we cannot exclude the possibility … WebJan 9, 2024 · GPR146 is an orphan G-protein 24coupled receptorthat is located on plasma membrane and responses to stimulation of heat- 25inactivated serum. Disruptinggpr146specifically in the liverdecreases the blood cholesterol 26leveland prevents high-fat or high-fat high-cholesterol diets induced hypercholesterolemia in 27mice.
WebProduct name Anti-GPCR GPR146 antibody See all GPCR GPR146 primary antibodies Description Rabbit polyclonal to GPCR GPR146 Host species Rabbit Tested applications Suitable for: WB more details Species reactivity Reacts with: Human Predicted to work with: Monkey Immunogen WebGPR146 Antibodies Antibodies that detect GPR146 can be used in several scientific applications, including Immunohistochemistry, Western Blot, ELISA and Immunocytochemistry. These antibodies target GPR146 in Human, Rat, Mouse and Monkey samples. Our GPR146 polyclonal antibodies are developed in Rabbit. Find the …
WebMay 9, 2024 · GPR146 was first identified in 2005 through comprehensive searches of the NCBI nonredundant protein database [ 15. ], with partial sequences known before that time named AXOR120 or probable GPCR PGR8 [ 16. ]. Human GPR146 is located on chromosome 7p22.3 and encodes a 333-amino acid seven-transmembrane (TM) protein. Web3 hours ago · TOTUM-070 is a patented polyphenol-rich blend of five different plant extracts showing separately a latent effect on lipid metabolism and potential synergistic properties. In this study, we investigated the health benefit of such a formula. Using a preclinical model of high fat diet, TOTUM-070 (3 g/kg of body weight) limited the HFD-induced hyperlipemia …
WebDec 17, 2024 · In agreement with previous human genetic studies that identified GPR146 as a potential regulator of plasma LDL-cholesterol (LDL-C) levels, Yu et al. found that …
WebNov 27, 2024 · In line with human genetic findings showing that increased expression of GPR146 is associated with elevated plasma TC levels, plasma TC levels were significantly reduced by 20% in male and by 25% in female Gpr146−/− mice fed chow compared to Gpr146+/+ littermates (16 h fasted, 16-week old male: 63.9 ± 7.3 mg/dl versus 80.4 ± 6.8 … pay online taxes monroe 08831WebSeveral studies have indicated that GPR146 is a putative receptor for C-peptide [49]. Previous reports have demonstrated that GPR146 plays a vital role in the regulation of plasma cholesterol... scribble hub dream engineWebAntibodies that detect GPR146 can be used in several scientific applications, including Immunohistochemistry, Western Blot, ELISA and Immunocytochemistry. These … scribblehub girls loveWebHypercholesterolemia risk-associated GPR146 is an orphan G-protein coupled receptor that regulates blood cholesterol levels in humans and mice Cell Res . 2024 Apr;30(4):363 … pay online surveyWebG Protein-coupled Receptor (GPCR) Deorphanization. We developed the first – and we believe the only – high-throughput system to identify synthetic ligands, including … scribblehub haremWebNov 27, 2024 · Here we demonstrate that orphan G protein-coupled receptor 146 (GPR146) promotes activity of hepatic sterol regulatory element binding protein 2 (SREBP2) … pay online tata power billWebSep 1, 2024 · GPR146 is a potential new therapeutic target for lipid lowering. Nat Rev Cardiol. 2024; 17:132–133. doi: 10.1038/s41569-019-0328-5 Crossref Google Scholar; 8. Yosten GL, Kolar GR, Redlinger LJ, Samson WK. Evidence for an interaction between proinsulin C-peptide and GPR146. J Endocrinol. payonlineticket.com