Bombesin-saporin
WebMice were given a single intrathecal injection of Bombesin-saporin (400 ng). Intrathal OT-induced scratching bouts was then recorded for 30 min two weeks after Bombesin … WebOct 18, 2024 · The neurotoxin bombesin–saporin (BB-sap) binds to and is internalized by GRPR neurons; however, it is not internalized by those expressing the related receptor …
Bombesin-saporin
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WebMice were given a single intrathecal injection of Bombesin-saporin (400 ng). Intrathal OT-induced scratching bouts was then recorded for 30 min two weeks after Bombesin-saporin injection. Data are ... WebOct 18, 2024 · The neurotoxin bombesin–saporin (BB-sap) binds to and is internalized by GRPR neurons; however, it is not internalized by those expressing the related receptor …
WebNov 1, 2014 · Intrathecal administration of the neurotoxin bombesin-saporin reduces or abolishes pruritogen-evoked scratching behavior. We investigated whether spinal neurons that respond to intradermal (ID) injection of pruritogens also respond to spinal superfusion of bombesin and vice versa. Single-unit recordings were made from superficial lumbar … WebOct 30, 2015 · Although intrathecal injection of a GRPR antagonist or ablation of GRPR-expressing neurons with conjugated bombesin-saporin (fig. S6) was effective in blocking chloroquine-evoked itch (Fig. 3, D and F), these manipulations failed to blunt scratching in response to mechanical stimulation in NPY::Cre IN–ablated mice (Fig. 3, C and E). ...
WebJun 13, 2024 · Immunotoxin 192-IgG-SAP (192-Saporin) 192-IgG-SAP is a chemical conjugate of the mouse monoclonal antibody 192-IgG that recognizes low affinity neurotrophin receptor and the ribosome-inactivating protein, Saporin. This anti-neuronal immunotoxin permanently eliminates cholinergic neurons of the basal forebrain (CBF), … WebJun 20, 2012 · 0.13 µg of stable SP-saporin (SSP-saporin) or 1.3 µg of bombesin-saporin or 10 µg of blank- saporin (Advanced Targeting System, San Diego in 20µl of PBS) were administered to the lumbar 4 to 5 ...
WebBombesin-SAP [IT-40, KIT-40] a tool for eliminating cells that express gastrin releasing peptide (GRP) receptor; targeted via bombesin, eliminated via saporin. Bombesin is a … Anti-DAT-SAP is a chemical conjugate of a rat monoclonal antibody to the second …
Webnoun. bom· be· sin ˈbäm-bə-sin. : a polypeptide that is found in the brain and gastrointestinal tract and has been shown experimentally to cause the secretion of various substances … summers creative studioWebNMB-saporin (NMB-sap) results in efficient ablation while bombesin-saporin (Bomb-sap) or blank-saporin (blank-sap) have no effect on NMBR-expressing cells. Cells transfected … summers county wv homes for saleWebOct 1, 2009 · Bombesin is a 14-amino acid peptide that was originally isolated from the skin of a frog, and gastrin-releasing peptide (GRP) is a mammalian homolog of bombesin. … summers county wv school calendarWebSep 1, 2024 · Bombesin-saporin treatment. The mice were given a single i.t. injection of bombesin-saporin (400 ng/mouse) or blank-saporin (400 ng/mouse). These mice were … summers co. wv funeral homespal combat knivesWebMice were given a single intrathecal injection of blank-saporin (400 ng/5 µl), bombesin-saporin (200, 300, 400 ng/5 µl) or saline (5 µl). Mice were used for behavior experiments at 2 weeks after the treatment. Some mice were perfused at 2 or 4 weeks after treatment for molecular marker analysis. Itch behavior summers county wv circuit courtWebFeb 14, 2012 · We found that after stimulation with both histamine and chloroquine, fewer Fos‐positive cells were present in mice treated with bombesin–saporin compared with … palcort tech sas